Drug induced liver damage affects approximately a fifth of prescribed drugs, according to recent research published in the journal Toxicology Reports.
Dili cases, also known as toxic hepatitis or hepatotoxicity, have increased in Western countries since the 1960s.
The condition represents an important cause of acute liver insufficiency. Potential triggers include plant -based products, food supplements and medicines, the study revealed.
The main function of the liver is to break down the substances taken orally, including supplements and drugs, according to the American College of Gastroenterology.
Paracetamol is most likely to cause liver damage
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For some people, the process of metabolization of these substances may be slower, which increases the risk of liver damage.
Even drugs tested for safety and approved by the United States Food and Drug Administration can potentially cause liver damage in rare cases.
The recent study of toxicology reports has identified several drugs most likely to cause liver damage.
Paracetamol, an over-the-counter an enlarged analgesic, is at the top of the list alongside non-steroidal anti-inflammatory drugs (NSAIDs), which are often used to treat headache, fever and chronic inflammatory disorders. In 2023, general practitioners established 14.8 million paracetamol prescriptions in England only – costing 47.8 million pounds Sterling, according to official NHS statistics.
Aspirin, commonly used as a fever, analgesic and blood slimming, also has risks.
Other drugs include nimesulide, methotrexate, corticosteroids, isoniazid, tetracyclines and halothane.
According to a 2024 study published in Jama Network Open 2004 and 2014, dili cases linked to plant or food supplements almost tripled between 2004 and 2014.
This spectacular increase highlights increasing concerns concerning the safety of supplements alongside traditional pharmaceutical risks.
Those who have preexisting liver conditions are higher of damage caused by the liver
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Those who have pre -existing liver conditions and nutritional deficiencies are faced with higher risks of Dili development, as are pregnant women.
The American College of Gastroenterology notes that some people can undergo a slower metabolism of drugs and supplements, increasing their vulnerability more.
Current symptoms of liver disease include nausea, loss of appetite, abdominal pain, generalized itching, dark urine and jaundice. However, some people may not notice any sign, which makes early detection difficult.
The growing incidence of liver damage induced by drugs highlights the importance of raising awareness of patients and health care providers.
Even apparently safe over -the -counter medication may have unexpected risks, especially for vulnerable populations who may not recognize warning signs until significant damage has occurred.