General anesthesia has proven to have the potentially added advantage of stimulating a neuroprotective effect against Alzheimer’s disease.
Xenon is an colorless and odorless noble gas used for many purposes in science, but a recent study in mice revealed that it stimulated the resident immune system of the brain, which can protect against Alzheimer’s disease, leading to a Reduced neuroinflammation, minimized brain atrophy and has favored protective neural states.
Alzheimer’s disease is the most common neurodegenerative disease in humans. According to the construction of toxic proteins called tau and beta-amyloid in the brain, drugs that eliminate these problems could not slow the progression of the disease. Consequently, neither the driver nor the healing is well understood.
Microglia, the most common brain immune cell plays an essential role in prevention of cognitive decline throughout life and, coupled with cerebral vertebral fluid, actually helps to eliminate tau and amyloid proteins.
Inhaled xenon gas was found In the laboratory, Brigham and Women’s Hospital to treat a model of Alzheimer’s mouse in which a group suffered from an accumulation of tau, and a second of an accumulation of beta-amyloid.
Capable of crossing the blood-brain barrier, xenon gas seemed to withdraw the mice, which began to become particularly active in the building and maintain their nests. The exams after the trial revealed that the gas induced and increased a typical protective microglial response of the type that erases tau and beta-amyloid proteins.
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“It is a very new discovery showing that inhalation of simple inert gas can have such a deep neuroprotective effect,” said Oleg Butovsky, doctorate and director of the laboratory, senior and co-corners, Brigham and Women’s.
“One of the main limits in the field of research and treatment of Alzheimer’s disease is that it is extremely difficult to conceive of drugs that can pass the blood -brain – but xenon gas barrier. We look forward to seeing this new approach tested in humans. »»
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“It is fascinating that in the two animal models which model different aspects of Alzheimer’s disease, amyloid pathology in a model and tau pathology in another model, that Xenon has had protective effects in both situations,” Declared David, author of co-corners, David M. Holtzman, md.
Healthy volunteers are currently registered in the hospital for a phase 1 test on dosage and security. SCI TECH DAILY reports The team also designs technologies to help use xenon gases more efficiently as well as recycling it.
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