Research on cancer treatment of more than 10 years of manufacture was born remarkable fruits with juicy potential to considerably improve existing radiotherapy.
Throughout the 21st century, GNN reported How cancer research has extendedenlarged, become more precise And more indulgent on non -cancer cells, and even showed how cancer can be beaten without ever having to fight.
Since the time of chemo and radiotherapy that often left patients exhausted, hairless and unable to keep the weight, there are now many more options that increase survival rates while reducing side effects.
In 2013, researcher UC San Francisco Kevan Shokat was looking to end A 30 -year expectation for a method to target the largest tumor growth engine, known as Kras. This protein, when mutated, causes unlimited cell proliferation, allowing small balloon tumors and goes back if it is narrowed.
Shokat succeeded by developing a drug that only targeted the mutated version of Kras, present in almost a third of all cancers, but which is even more widespread in pulmonary, pancreatic and cancerous tumors of the colon.
However, his discovery of the way of targeting kras has never matured in an infallible way of destroying it – future experiences showed how tumors that have lost Kras proteins would return.
“We suspected very early that KRAS drugs could serve as permanent flags for cancer cells,” said Charly Craik, PHD, professor of pharmaceutical chemistry at the UCSF and co-author of the study, at UCSF Press.
Craraik, with Shokat in his team, has now used The drug already approved by the FDA called Sotorasib to report tumors containing Kras, then triggered a radioactive antibody to search and bind, the SotoraSib acting as a waypoint.
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“This is a punch,” said Craraik. “We could potentially kill tumors before we can develop resistance.”
“The beauty of this approach is that we can calculate an extremely safe dose of radiation. Unlike the radiation of the external beam, this method only uses the amount of radiation necessary to beat cancer. »»
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There are several ways in which an individual’s cells are coded to display Sotorasib, and the development of antibodies to respond precisely to this individuality would be a key step to see this intervention in a hospital near you; But unlike experimental drugs, Sotorasib is already approved by the FDA.
The radioactivity of the antibody comes from the isotope zirconium-89, which is already used in a medical imaging technology called positron emission tomography, often called TEP, which uses it in the same way as Craraik has it Used – integrating it inside an antibody.
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